The Kutys Lab spans disciplinary boundaries between cell biology and engineering to investigate tissue morphogenic processes associated with human development, regeneration and disease.

Ultimately, we are interested in uncovering fundamental molecular and mechanical mechanisms that conspire across time and length scales to organize and shape human tissues. To do so, we develop microfluidic, biomimetic human tissue models that recapitulate 3D in vivo architectures, microenvironments, cellular heterogeneity, and morphogenic behaviors that can be examined mechanistically by biochemical and cell biological approaches. Combined with advanced microscopy, cellular and molecular engineering, and 'omic' technologies, our multidisciplinary approach allows us to model, control, and dissect complex multicellular behaviors at a level previously only accessible in vivo. 

Our collective efforts will 1) lead to an improved understanding of the breakdown of these control systems in cancer and cardiovascular disease and 2) inform design strategies for regenerative medicine as well as the next generation of preclinical test beds. ​The Kutys Lab resides within the Department of Cell and Tissue Biology at the University of California San Francisco Parnassus Campus.

Our lab is generously supported by:

Recent Lab News:

NEW GRANT! The lab is awarded a R21 award from the NIA to study Notch/APP interplay in cerebral small vessel disease!

NEW PUB! Check out our recent contribution to understanding mechanics and mechanisms of 3D mesenchymal migration in Dev Cell!

The lab welcomes 2021 Winter and Spring PhD rotation students Kyle Jacobs (BMS), Haley Smith (DSCB), and Lakyn Mayo (MSTP)!

Check the News page for more lab news!